TY - JOUR AU - Carroll, Sean AB - Do new anatomical structures arise de novo, or do they evolve from pre-existing structures? Advances in developmental genetics, palaeontology and evolutionary developmental biology have recently shed light on the origins of some of the structures that most intrigued Charles Darwin, including animal eyes, tetrapod limbs and giant beetle horns. In each case, structures arose by the modification of pre-existing genetic regulatory circuits established in early metazoans. The deep homology of generative processes and cell-type specification mechanisms in animal development has provided the foundation for the independent evolution of a great variety of structures. TI - Deep homology and the origins of evolutionary novelty JF - Nature DO - 10.1038/nature07891 DA - 2009-02-11 UR - https://www.deepdyve.com/lp/springer-journals/deep-homology-and-the-origins-of-evolutionary-novelty-DqGO16gvv5 SP - 818 EP - 823 VL - 457 IS - 7231 DP - DeepDyve ER -