TY - JOUR AU - AB - Downloaded from genesdev.cshlp.org on November 10, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION A/CDK2. Recently, a transcriptional repressor with ho- A specific, nonproliferative mology to E2F, EMA, which lacks both pocket protein- binding and cyclin-binding sequences, was described role for E2F-5 in choroid (Morkel et al. 1997). The complexity of E2F activity, gen- plexus function revealed erated by the formation of different heterodimeric E2F/ by gene targeting DP and pocket protein complexes, suggests distinct and diverse functions in cellular growth control. 1,2 3 Geoffrey J. Lindeman, Lina Dagnino, E2F transcription factors are important for G -toS- 1 1 4 Stefan Gaubatz, Yuhui Xu, Roderick T. Bronson, phase entry. In Drosophila, where only one E2F member 5 1,6 has been identified, E2F is critical for S-phase progres- Henry B. Warren, and David M. Livingston sion beyond the seventeenth division in embryogenesis The Dana-Farber Cancer Institute/Harvard Medical School, (Duronio et al. 1995). In mammals, overexpression of Boston, Massachusetts 02115 USA; Ottawa General Hospital E2F-1, the best characterized member, is sufficient to Research Institute, Ottawa, Ontario K1H 8L6 Canada; Tufts induce S-phase entry in quiescent (G ) cells (Johnson et University School of Veterinary Medicine, Boston, al. 1993; TI - A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting JF - Genes & Development DO - 10.1101/gad.12.8.1092 DA - 1998-04-15 UR - https://www.deepdyve.com/lp/unpaywall/a-specific-nonproliferative-role-for-e2f-5-in-choroid-plexus-function-E3AoWlQXfd DP - DeepDyve ER -