TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275, No. 3, Issue of January 21, pp. 1625–1629, 2000 © 2000 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. (Received for publication, August 3, 1999) Gergely L. Lukacs‡§, Peter Haggie, Olivier Seksek, D. Lechardeur‡, Neal Freedman, and A. S. Verkman¶ From the Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0521 and ‡Program in Cell and Lung Biology, Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1X8, Canada The diffusion of DNA in cytoplasm is thought to be an introduced DNA fragments in cytoplasm and nucleus. It is not known whether the diffusion of DNA fragments is hindered by important determinant of the efficacy of gene delivery and antisense therapy. We have measured the transla- binding and steric interactions or how the size and physical tional diffusion of fluorescein-labeled double-stranded structure of DNA affect its diffusional properties. DNA fragments (in base pairs (bp): 21, 100, 250, 500, 1000, Recent studies have provided information about the diffu- 2000, 3000, 6000) after microinjection into cytoplasm and sional mobilities of small and macromolecule-sized solutes in nucleus 
TI - Size-dependent DNA Mobility in Cytoplasm and Nucleus
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.275.3.1625
DA - 2000-01-01
UR - https://www.deepdyve.com/lp/unpaywall/size-dependent-dna-mobility-in-cytoplasm-and-nucleus-E51GTO9kmg
DP - DeepDyve
ER -