TY - JOUR
AU - Zhang, Xian-Zheng
AB - A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host-guest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy. 
TI - Rational Design of Multifunctional Gold Nanoparticles via Host-Guest Interaction for Cancer-Targeted Therapy.
JF - ACS Applied Materials & Interfaces
DO - 10.1021/acsami.5b04031
DA - 2016-07-19
UR - https://www.deepdyve.com/lp/pubmed/rational-design-of-multifunctional-gold-nanoparticles-via-host-guest-F9cPUsQpuy
SP - 17171
EP - 80
VL - 7
IS - 31
DP - DeepDyve
ER -