TY - JOUR AU1 - Brassen, Stefanie AU2 - Gamer, Matthias AU3 - Peters, Jan AU4 - Gluth, Sebastian AU5 - Büchel, Christian AB - Life-span theories explain successful aging with an adaptive management of emotional experiences like regret. As opportunities to undo regrettable situations decline with age, a reduced engagement into these situations represents a potentially protective strategy to maintain well-being in older age. Yet, little is known about the underlying neurobiological mechanisms supporting this claim. We used a multimodal psychophysiological approach in combination with a sequential risk-taking task that induces the feeling of regret and investigated young as well as emotionally successfully and unsuccessfully (i.e., late-life depressed) aged participants. Responsiveness to regret was specifically reduced in successful aging paralleled by autonomic and frontostriatal characteristics indicating adaptive shifts in emotion regulation. Our results suggest that disengagement from regret reflects a critical resilience factor for emotional health in older age. TI - Don't look back in anger! Responsiveness to missed chances in successful and nonsuccessful aging. JF - Science (New York, N.Y.) DO - 10.1126/science.1217516 DA - 2012-05-17 UR - https://www.deepdyve.com/lp/pubmed/don-t-look-back-in-anger-responsiveness-to-missed-chances-in-FaucEc1mZg SP - 612 EP - 4 VL - 336 IS - 6081 DP - DeepDyve ER -