TY - JOUR
AU - Gilmore, Thomas D
AB - Oncogene (1999) 18, 6842 ± 6844 ã 1999 Stockton Press All rights reserved 0950 ± 9232/99 $15.00 http://www.stockton-press.co.uk/onc The Rel/NF-kB signal transduction pathway: introduction ,1 Thomas D Gilmore* Biology Department, Boston University, 5 Cummington Street, Boston, Massachusetts, MA 02215-2406, USA Keywords: Rel; NF-kB; IkB; IKK; signal transduction; is that of IkBa with NF-kB, and this interaction blocks transcription factor the ability of NF-kB to enter the nucleus and bind to DNA. From biochemical studies and, more recently, direct structural determinations (Chen and Ghosh, Introduction 1999), it is clear that IkBa makes multiple contacts with NF-kB. These interactions cover the nuclear Rel/NF-kB transcription factors include a collection of localization sequence of NF-kB and interfere with proteins, conserved from Drosophila to humans (Figure sequences important for DNA binding. 1). Among model organisms, these transcription factors Thus, in most cells, NF-kB is present as a latent, are notably absent in yeast and C. elegans; in part, this inactive, IkB-bound complex in the cytoplasm. When a may be because one of the primary roles of these cell receives any of a multitude of extracellular signals factors is to control a variety of physiological aspects (see Pahl, 1999), NF-kB rapidly enters the nucleus and 
TI - The Rel/NF-κB signal transduction pathway: introduction
JF - Oncogene
DO - 10.1038/sj.onc.1203237
DA - 1999-11-22
UR - https://www.deepdyve.com/lp/springer-journals/the-rel-nf-b-signal-transduction-pathway-introduction-Fu4S7Isv1o
SP - 6842
EP - 6844
VL - 18
IS - 49
DP - DeepDyve
ER -