TY - JOUR AU1 - Collinge, John AU2 - Sidle, Katie C. L. AU3 - Meads, Julie AU4 - Ironside, James AU5 - Hill, Andrew F. AB - Strains of transmissible spongiform encephalopathies are distinguished by differing physico-chemical properties of PrPSc, the disease-related isoform of prion protein, which can be maintained on transmission to transgenic mice. 'New variant' Creutzfeldt–Jakob disease (CJD) has strain characteristics distinct from other types of CJD and which resemble those of BSE transmitted to mice, domestic cat and macaque, consistent with BSE being the source of this new disease. Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype. TI - Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD JF - Nature DO - 10.1038/383685a0 DA - 1996-10-24 UR - https://www.deepdyve.com/lp/springer-journals/molecular-analysis-of-prion-strain-variation-and-the-aetiology-of-new-GI0Dn26LUF SP - 685 EP - 690 VL - 383 IS - 6602 DP - DeepDyve ER -