TY - JOUR
AU - Hill, Andrew F.
AB - Strains of transmissible spongiform encephalopathies are distinguished by differing physico-chemical properties of PrPSc, the disease-related isoform of prion protein, which can be maintained on transmission to transgenic mice. 'New variant' Creutzfeldt–Jakob disease (CJD) has strain characteristics distinct from other types of CJD and which resemble those of BSE transmitted to mice, domestic cat and macaque, consistent with BSE being the source of this new disease. Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype.
TI - Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
JF - Nature
DO - 10.1038/383685a0
DA - 1996-10-24
UR - https://www.deepdyve.com/lp/springer-journals/molecular-analysis-of-prion-strain-variation-and-the-aetiology-of-new-GI0Dn26LUF
SP - 685
EP - 690
VL - 383
IS - 6602
DP - DeepDyve
ER -