TY - JOUR
AU - Wang, Xiao-Fan
AB - Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans. Deregulation of TGF-β/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-β/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects and eventually desirable biological outcomes. The nature of such signaling cross-talk is overwhelmingly complex and highly context-dependent. Here we review the different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines, with an emphasis on the underlying molecular mechanisms.
TI - Signaling cross-talk between TGF-β/BMP and other pathways
JF - Cell Research
DO - 10.1038/cr.2008.302
DA - 2008-11-11
UR - https://www.deepdyve.com/lp/springer-journals/signaling-cross-talk-between-tgf-bmp-and-other-pathways-H72j4qFVkB
SP - 71
EP - 88
VL - 19
IS - 1
DP - DeepDyve
ER -