TY - JOUR
AU - Svozil, Daniel
AB - Background: Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their tertiary and quaternary structures. While structural superposition of short RNAs is achievable in a reasonable time, large structures represent much bigger challenge. Therefore, we have developed a fast and accurate algorithm for RNA pairwise structure superposition called SETTER and implemented it in the SETTER web server. However, though biological relationships can be inferred by a pairwise structure alignment, key features preserved by evolution can be identified only from a multiple structure alignment. Thus, we extended the SETTER algorithm to the alignment of multiple RNA structures and developed the MultiSETTER algorithm. Results: In this paper, we present the updated version of the SETTER web server that implements a user friendly interface to the MultiSETTER algorithm. The server accepts RNA structures either as the list of PDB IDs or as user-defined PDB files. After the superposition is computed, structures are visualized in 3D and several reports and statistics are generated. Conclusion: To the best of our knowledge, the MultiSETTER web server is the first publicly available tool for a multiple RNA structure alignment. The MultiSETTER server offers the visual inspection of an alignment in 3D 
TI - MultiSETTER: web server for multiple RNA structure comparison
JF - BMC Bioinformatics
DO - 10.1186/s12859-015-0696-8
DA - 2015-08-12
UR - https://www.deepdyve.com/lp/springer-journals/multisetter-web-server-for-multiple-rna-structure-comparison-H8mG0QFOJ0
SP - 1
EP - 8
VL - 16
IS - 1
DP - DeepDyve
ER -