TY - JOUR AU1 - Koch, M. AU2 - Robbins, T. AB - Psychopharmacology (2001) 156:360–367 DOI 10.1007/s002130100829 ORIGINAL INVESTIGATION Peggy Postma · Veena Kumari · Tonmoy Sharma Melissa Hines · Jeffrey A. Gray Startle response during smoking and 24 h after withdrawal predicts successful smoking cessation Received: 14 March 2001 / Accepted: 9 May 2001 / Published online: 22 June 2001 © Springer-Verlag 2001 Abstract Rationale: The startle response is thought to cific response profiles may be predictive of the ability to reflect changes in attentional processes in humans. The quit smoking. startle response shows a number of forms of plasticity, of which prepulse inhibition (PPI) refers to the attenuation Keywords Acoustic startle response · Prepulse of the startle response to a strong sensory stimulus inhibition · Nicotine · Smoking cessation (pulse), when such a pulse is preceded by a stimulus of lower intensity (prepulse). Recent studies have shown that nicotine modulates startle and PPI of the startle re- Introduction flex in humans and animals. The present study examined individual differences in cognitive benefits obtained Explanations of the underlying mechanisms of smoking from smoking as indexed by startle response and PPI. dependence have traditionally focussed on neurobiologi- Objectives: We investigated, using a within-subjects de- cal accounts, such as nicotine’s interaction with TI - Special issue on the psychopharmacology of prepulse inhibition: basic and clinical studies JF - Psychopharmacology DO - 10.1007/s002130100826 DA - 2001-07-01 UR - https://www.deepdyve.com/lp/springer-journals/special-issue-on-the-psychopharmacology-of-prepulse-inhibition-basic-HBEHZjeUsk SP - 115 EP - 116 VL - 156 IS - 2 DP - DeepDyve ER -