TY - JOUR
AU1 - Benjamin, Emelia J.
AU2 - Rice, Kenneth M.
AU3 - Arking, Dan E.
AU4 - Pfeufer, Arne
AU5 - van Noord, Charlotte
AU6 - Smith, Albert V.
AU7 - Schnabel, Renate B.
AU8 - Bis, Joshua C.
AU9 - Boerwinkle, Eric
AU1 - Sinner, Moritz F.
AU1 - Dehghan, Abbas
AU1 - Lubitz, Steven A.
AU1 - D’Agostino, Ralph B.
AU1 - Lumley, Thomas
AU1 - Ehret, Georg B.
AU1 - Heeringa, Jan
AU1 - Aspelund, Thor
AU1 - Newton-Cheh, Christopher
AU1 - Larson, Martin G.
AU2 - Marciante, Kristin D.
AU2 - Soliman, Elsayed Z.
AU2 - Rivadeneira, Fernando
AU2 - Wang, Thomas J.
AU2 - Eiriksdottir, Gudny
AU2 - Levy, Daniel
AU2 - Psaty, Bruce M.
AU2 - Li, Man
AU2 - Chamberlain, Alanna M.
AU2 - Hofman, Albert
AU3 - Vasan, Ramachandran S.
AU3 - Harris, Tamara B.
AU3 - Rotter, Jerome I.
AU3 - Kao, W.H. Linda
AU3 - Agarwal, Sunil K.
AU3 - Ch. Stricker, Bruno H.
AU3 - Wang, Ke
AU3 - Launer, Lenore J.
AU3 - Smith, Nicholas L.
AU3 - Chakravarti, Aravinda
AU4 - Uitterlinden, Andre G.
AU4 - Wolf, Philip A
AU4 - Sotoodehnia, Nona
AU4 - Kottgen, Anna
AU4 - van Duijn, Cornelia M.
AU4 - Lunetta, Kathryn L.
AU4 - Heckbert, Susan R.
AU4 - Gudnason, Vilmundur
AU4 - Alonso, Alvaro
AU4 - Kaab, Stefan
AU5 - Ellinor, Patrick T.
AU5 - Witteman, Jacqueline C.
AB - We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
TI - Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
JF - Nature genetics
DO - 10.1038/ng.416
DA - 2009-07-13
UR - https://www.deepdyve.com/lp/pubmed-central/variants-in-zfhx3-are-associated-with-atrial-fibrillation-in-HTHVKl7YK1
SP - 879
EP - 881
VL - 41
IS - 8
DP - DeepDyve
ER -