TY - JOUR
AU1 - Majerfeld, Irene
AU2 - Yarus, Michael
AB - We have isolated an RNA with specific affinity for the L-valine side chain, using selection-amplification. The active RNA secondary structure, identified by repeated selection, is a highly conserved asymmetric (4:10) internal loop adjacent to required G-U pairs. The binding free-energy per methylene is up to 1.5 kcal mol−1 and very dependent on group position. Amino acid binding is L-stereoselective and distinguishes aliphatic sidechains by size and, given the same total size, by configuration. Though aliphatic-RNA interactions have frequently been neglected, their avidity and specificity seem sufficient for a biological role.
TI - An RNA pocket for an aliphatic hydrophobe
JF - Nature Structural & Molecular Biology
DO - 10.1038/nsb0594-287
DA - 1994-05-01
UR - https://www.deepdyve.com/lp/springer-journals/an-rna-pocket-for-an-aliphatic-hydrophobe-I351ES8C9h
SP - 287
EP - 292
VL - 1
IS - 5
DP - DeepDyve
ER -