TY - JOUR
AU - 
AB - Original article 45 The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study a b a,b a Maryam Omidvar , Lisette Stolk , Andre G. Uitterlinden , Albert Hofman , a a,c Cornelia M. Van Duijn and Henning Tiemeier Objective The Met/Val functional polymorphism of the 95% CI: 0.63–1.01, P = 0.06). In the pooled analyses of gene-encoding catechol-O-methyltransferase (COMT) is prevalent and incident cessation cases that we compared one of the most widely tested variants for association with with persisting smokers, the odds ratio was 0.70 (95% CI: different phenotypes of addictive behavior, but replication 0.55–0.88, P = 0.003). No sex difference and no effect of the has been inconsistent for smoking status. We investigated COMT polymorphism on smoking initiation were observed. the relationship of this COMT single nucleotide polymorphism with smoking cessation in elderly persons Conclusion Our results suggest that COMT Met/Val in retrospective and prospective analyses. polymorphism is strongly associated with smoking cessation. The Met allele is the risk allele that decreases Methods The study is embedded in the population-based the likelihood of smoking cessation in men and Rotterdam Study cohort and included 5115 persons aged women. Pharmacogenetics 
TI - The effect of catechol- O
JF - Pharmacogenetics & Genomics
DO - 10.1097/FPC.0b013e328317f3f8
DA - 2009-01-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/the-effect-of-catechol-o-I9Ej6hSU6X
SP - 45
EP - 51
VL - 19
IS - 1
DP - DeepDyve
ER -