TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273, No. 14, Issue of April 3, pp. 8240 –8247, 1998 Printed in U.S.A. The Cyclic Adenosine Monophosphate-dependent Protein Kinase (PKA) Is Required for the Sustained Activation of Mitogen-activated Kinases and Gene Expression by Nerve Growth Factor* (Received for publication, September 11, 1997, and in revised form, January 16, 1998) Hong Yao‡§, Randall D. York‡¶, Anita Misra-Press‡, Daniel W. Carri, and Philip J. S. Stork‡**‡‡ From the ‡Vollum Institute for Advanced Biomedical Research, §Department of Molecular Microbiology and Immunology, ¶Neuroscience Graduate Program, **Departments of Pathology and Cell and Developmental Biology, and iVeterans Affairs Medical Center and the Division of Endocrinology, Oregon Health Sciences University, Portland, Oregon 97201 Induction of neuronal differentiation of the rat pheo- complex that includes the small monomeric G protein Ras (7). chromocytoma cell line, PC12 cells, by nerve growth Ras activation triggers a cascade of phosphorylations on pro- factor (NGF) requires activation of the mitogen-acti- tein kinases that lie upstream of the ERKs (8). Epidermal vated protein (MAP) kinase or extracellular signal-reg- growth factor (EGF) also induces ERK activation via Ras. Un- ulated kinase (ERK). cAMP-dependent protein kinase like that of NGF, the EGF activation of Ras and ERK 
TI - The Cyclic Adenosine Monophosphate-dependent Protein Kinase (PKA) Is Required for the Sustained Activation of Mitogen-activated Kinases and Gene Expression by Nerve Growth Factor
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.273.14.8240
DA - 1998-04-01
UR - https://www.deepdyve.com/lp/unpaywall/the-cyclic-adenosine-monophosphate-dependent-protein-kinase-pka-is-IStLmbt5lb
DP - DeepDyve
ER -