TY - JOUR AU - Quick, Armand J. AB - THE CLINICAL APPLICATION OF THE HIPPURIC ACID AND THE PROTHROMBIN TESTS* ARMAND J. QUICK Department of Pharmacology, Marquette University School of Medicine, Milwaukee A survey of recent advances in medicine and surgery yields numerable examples of problems solved by laboratory methods which had completely defied all approaches by purely clinical means. No better illustration can be cited than the recognized dangers confronting the jaundiced patient who required surgical treatment. All the surgeon's clinical experience availed him little in determining the extent to which the liver had been in­ jured; nevertheless this information was highly desirable for determining the type of anesthesia, the possible postoperative course, and numerous other factors. Furthermore while it was clearly recognized that every jaundiced patient was potentially in jeopardy of serious and occasional fatal hemorrhage, it was neither possible to predict clinically which subjects would bleed, nor to take steps to prevent this catastrophic complication. Two simple tests developed during the past six years have been ac­ cepted rather widely by American surgeons as definite aids, particularly in the surgery of the biliary tract in meeting the two problems just presented. The first of these tests is the hippuric acid synthesis as a means for TI - The Clinical Application of the Hippuric Acid and the Prothrombin Tests JF - American Journal of Clinical Pathology DO - 10.1093/ajcp/10.3.222 DA - 1940-03-01 UR - https://www.deepdyve.com/lp/oxford-university-press/the-clinical-application-of-the-hippuric-acid-and-the-prothrombin-Ie0RFCjkFB SP - 222 EP - 233 VL - 10 IS - 3 DP - DeepDyve ER -