TY - JOUR
AU - Foroud, Tatiana
AB - Background:  A wealth of literature supports the role of γ‐aminobutyric acid (GABA) in neurobiological pathways contributing to alcohol dependence and related phenotypes. Animal studies have consistently tied rodent homologs of the GABAA receptor genes on human chromosome 5q to alcohol‐related behaviors; however, human studies have produced mixed results. Family‐based association analyses previously conducted in the Collaborative Study on the Genetics of Alcoholism (COGA) sample yielded no evidence of association with Diagnostic and Statistical Manual of Mental Disorder—fourth edition (DSM‐IV) alcohol dependence and these genes. As a follow‐up to that study, we examined several alcohol‐related behaviors in the COGA sample as follows: (1) a broader definition of alcohol dependence, including DSM‐III‐R symptoms and Feighner criteria (referred to as COGA alcohol dependence); (2) withdrawal; (3) history of alcohol‐induced blackouts; (4) level of response to alcohol; (5) age of onset of regular drinking; and (6) age at first drunkenness.
TI - Association Between GABRA1 and Drinking Behaviors in the Collaborative Study on the Genetics of Alcoholism Sample
JF - Alcoholism: Clinical & Experimental Research
DO - 10.1111/j.1530-0277.2006.00136.x
DA - 2006-07-01
UR - https://www.deepdyve.com/lp/wiley/association-between-gabra1-and-drinking-behaviors-in-the-collaborative-J0ylDYoJAA
SP - 1101
EP - 1110
VL - 30
IS - 7
DP - DeepDyve
ER -