TY - JOUR
AU - Smith, D H
AB - Fifty-five clinical isolates and laboratory stocks of Escherichia coli and Salmonella were studied for resistance to each of ten metals. Eleven clinical isolates carrying R factors were resistant to mercury, and, in each case, the resistance was mediated by a previously undefined R-factor gene. The gene was phenotypically expressed within 2 to 4 minutes after entry into sensitive bacteria, but the basis for the resistance remains undefined. Fourteen strains, 12 infected with R factors, were resistant to cobalt and nickel, but these resistances were mediated by R-factor genes in only two strains; separate R-factor genes mediated the resistances to nickel and cobalt. These and other results indicate that the genetic composition of R factors is greater than that originally defined.
TI - R factors mediate resistance to mercury, nickel, and cobalt.
JF - Science (New York, N.Y.)
DO - 10.1126/science.156.3778.1114
DA - 1967-07-01
UR - https://www.deepdyve.com/lp/pubmed/r-factors-mediate-resistance-to-mercury-nickel-and-cobalt-J2O290VvDs
SP - 1114
EP - 6
VL - 156
IS - 3778
DP - DeepDyve
ER -