TY - JOUR
AU - Verma, Rajeshwar Prasad
AB - DRUG METABOLISM REVIEWS Vol. 36, No. 1, pp. 105–156, 2004 Corwin Hansch, Suresh Babu Mekapati, Alka Kurup, and Rajeshwar Prasad Verma Department of Chemistry, Pomona College, Claremont, California, USA Key Words: QSAR; Cytochrome P450; ADME. The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new drugs must be concerned with. While there are various ways in which organic compounds can undergo metabolic attack, P450 is probably the most important. Recently, Lewis (2000) reviewed his extensive studies on P450 and efforts to use QSAR to gain a deeper understanding on this important class of enzymes. We have also been interested in the QSAR of P450 enzymes, but much has appeared since our last review (Hansch and Zhang, 1993). INDUCTION OF CYTOCHROME P450 The induction of P450 enzymes by various chemicals has received very little attention, despite its great importance. In fact, the work by our group is all that we could find. Correspondence: Corwin Hansch, Department of Chemistry, Pomona College, Claremont, CA, 91711, USA; E-mail: corwin.hansch@pomona.edu. DOI: 10.1081/DMR-120028428 0360-2532 (Print); 1097-9883 (Online) Copyright D 2004 by Marcel Dekker, Inc. www.dekker.com ORDER REPRINTS 
TI - QSAR of Cytochrome P450
JF - Drug Metabolism Reviews
DO - 10.1081/DMR-120028428
DA - 2004-01-01
UR - https://www.deepdyve.com/lp/taylor-francis/qsar-of-cytochrome-p450-JID0y4ZfOa
SP - 105
EP - 156
VL - 36
IS - 1
DP - DeepDyve
ER -