TY - JOUR
AU1 - Pomero, F.
AU2 - Allione, A.
AU3 - Molinar Min, A.
AU4 - La Selva, M.
AU5 - Porta, M.
AB - Acta Diabetol (2000) 37:103 © Springer-Verlag 2000 LETTER F. Pomero • A. Allione • A. Molinar Min • M. La Selva • M. Porta Thiamine, beta-cell function and peripheral glucose utilization in thiamine-responsive megaloblastic anemia (TRMA) syndrome Sir: Valerio et al. [1] failed to observe any effects on meta- amine-deficient rats [4]. Data from our laboratory suggest bolic control and daily insulin requirements when benzoyl- that thiamine may also improve glucose utilization in non- oxymethyl-thiamine, a lipophilic derivative of thiamine (vit- insulin-sensitive tissues, such as human and bovine amin B ), was administered to patients with insulin depen- endothelial cells cultured in the presence of high (28 dent diabetes mellitus (IDDM). Since the same authors had mmol/l) glucose [5]. However, normalization of lactate pro- reported previously that thiamine administration reduces duction was observed for levels of thiamine much higher exogenous insulin requirements in patients with thiamine- than those measured in the blood, although accumulation of at specific tissue sites cannot be ruled out. responsive megaloblastic anemia (TRMA) [2], a rare syn- vitamin B However, the favorable effects of thiamine on glucose drome characterized by megaloblastic anemia, non-insulin metabolism in patients with TRMA, and lack thereof in dependent diabetes and 
TI - Thiamine, beta-cell function and peripheral glucose utilization in thiamine-responsive megaloblastic anemia (TRMA) syndrome
JF - Acta Diabetologica
DO - 10.1007/s005920070027
DA - 2000-11-01
UR - https://www.deepdyve.com/lp/springer-journals/thiamine-beta-cell-function-and-peripheral-glucose-utilization-in-JKtjvaQYE3
SP - 103
EP - 103
VL - 37
IS - 2
DP - DeepDyve
ER -