TY - JOUR
AU - Streilein, J. Wayne
AB -  Exposure to alloantigen via the anterior chamber of the eye elicits a transient suppression of cellular immunity, whereas humoral immunity is preserved—i.e. F1 LI-ID. The majority of lymphoid cells inoculated into the anterior chamber are retained within the posterior segment of the eye. The latter serves as a depot of alloantigen, allowing the chronic egress of small numbers of cells into the vascular tree. The persistence of this antigen depot is essential to the development of F1 LI-ID. Since there is a preferential distribution of cells that migrate from the eye to the spleen, the functional integrity of the latter is also necessary to elicit F1 LI-ID. It is concluded that an anatomically intact spleen, i.v. presentation of antigen, and persistence of antigen within the eye are all important to the elicitation of this phenomenon. 
TI - Immune Response to Immunization via the Anterior Chamber of the Eye
JO - Ocular Immunology and Inflammation
DO - 10.1080/09273940701382184
DA - 2007-01-01
UR - https://www.deepdyve.com/lp/taylor-francis/immune-response-to-immunization-via-the-anterior-chamber-of-the-eye-JZR1S07Q10
SP - 179
EP - 185
VL - 15
IS - 3
DP - DeepDyve
ER -