TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272, No. 49, Issue of December 5, pp. 30603–30606, 1997 Communication Printed in U.S.A. Human immunodeficiency virus (HIV-1) uses CD4 as the Mechanism of Transdominant primary receptor and chemokine co-receptors to enter target Inhibition of CCR5-mediated cells (1). Chemokine receptors belong to the superfamily of G protein-coupled receptors that have seven transmembrane do- HIV-1 Infection by ccr5D32* mains. Chemokines are a family of small proteins (7–16 kDa) that can be operationally divided in two subgroups. The a (Received for publication, August 27, 1997) subfamily (CXC) is distinguished from the b subfamily (CC) by Monsef Benkirane‡§¶, Dong-Yan Jin‡, the insertion of a single amino acid between the first and the Rene F. Chun‡, Richard A. Koup **, second cysteine residues. The binding of chemokines to their and Kuan-Teh Jeang‡** receptors induces a rapid calcium influx and inflammatory From the ‡Molecular Virology Section, Laboratory of responses (2). The CXC chemokine receptor for stromal cell- Molecular Microbiology, NIAID, National Institutes of derived factor-1 designated CXCR4 (3, 4) was initially shown to Health, Bethesda, Maryland 20892-0460, the §Centre de be a co-receptor for T-cell-tropic (T-tropic) HIV-1s (5). Based on Recherche de Biochimie Macromoleculaire CNRS, the finding that 
TI - Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Δ32
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.272.49.30603
DA - 1997-12-01
UR - https://www.deepdyve.com/lp/unpaywall/mechanism-of-transdominant-inhibition-of-ccr5-mediated-hiv-1-infection-K6vAsBOYmX
DP - DeepDyve
ER -