TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on October 17, 2021 - Published by Cold Spring Harbor Laboratory Press The Rel-associated pp40 protein prevents DNA binding of Rel and NF-KB: relationship .with IKBI3 and regulation by phosphorylatlon Lawrence D. Kerr, Jun-ichiro Inoue, Nathan Davis, 1 Egenhard Link, 2 Patrick A. Baeuerle, z Henry R. Bose Jr., 1 and Inder M. Verma Molecular Biology and Virology Laboratory, The Salk Institute, San Diego, California 92186-5800 USA; 1Department of Microbiology and The Cell Research Institute, The University of Texas at Austin, Austin, Texas 78712 USA; 2Laboratorium fur Molekulare Biologie der Ludwig-Maximilians-Universitat Munchen, D-8033 Martinsried, Germany. The product of proto-oncogene Rel associates with a number of cellular proteins. We have studied the effect of one of them, a phosphoprotein of 40 kD (pp40), on the DNA-binding activity of the Rel protein. We demonstrate that purified pp40 not only inhibits the binding of Rel, but also NF-KB (pS0-p65) heterocomplex to DNA. Additionally, IKBI3, but not IKB~, also prevented the binding of Rel to the KB site.. IKB[~ and pp40 are related proteins because (1) they share a number of common tryptic peptides, (2) their inhibitory effect on DNA binding can be abolished by preincubation with pp40-specific antiserum, and 
TI - The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.
JF - Genes & Development
DO - 10.1101/gad.5.8.1464
DA - 1991-08-01
UR - https://www.deepdyve.com/lp/unpaywall/the-rel-associated-pp40-protein-prevents-dna-binding-of-rel-and-nf-KP3ErNnWc4
DP - DeepDyve
ER -