TY - JOUR
AU1 - Jiménez-Marín, Ángeles
AU2 - Collado-Romero, Melania
AU3 - Ramirez-Boo, María
AU4 - Arce, Cristina
AU5 - Garrido, Juan
AB - Background: Once a list of differentially expressed genes has been identified from a microarray experiment, a subsequent post-analysis task is required in order to find the main biological processes associated to the experimental system. This paper describes two pathways analysis tools, ArrayUnlock and Ingenuity Pathways Analysis (IPA) to deal with the post-analyses of microarray data, in the context of the EADGENE and SABRE post-analysis workshop. Dataset employed in this study proceeded from an experimental chicken infection performed to study the host reactions after a homologous or heterologous secondary challenge with two species of Eimeria. Results: Analysis of the same microarray data source employing both commercial pathway analysis tools in parallel let to identify several biological and/or molecular functions altered in the chicken Eimeria maxima infection model, including several immune system related pathways. Biological functions differentially altered in the homologous and heterologous second infection were identified. Similarly, the effect of the timing in a homologous second infection was characterized by several biological functions. Conclusion: Functional analysis with ArrayUnlock and IPA provided information related to functional differences with the three comparisons of the chicken infection leading to similar conclusions. ArrayUnlock let an improvement of the annotations of the chicken genome adding 
TI - Biological pathway analysis by ArrayUnlock and Ingenuity Pathway Analysis
JF - BMC Proceedings
DO - 10.1186/1753-6561-3-S4-S6
DA - 2009-07-16
UR - https://www.deepdyve.com/lp/springer-journals/biological-pathway-analysis-by-arrayunlock-and-ingenuity-pathway-KcgBQMU3rN
SP - 1
EP - 6
VL - 3
IS - 4
DP - DeepDyve
ER -