TY - JOUR
AU - Weinmann, Amy S.
AB - SUMMARYT-bet and Bcl-6 are required to establish TH1 or TFH gene expression profiles, respectively. Here, we demonstrated that high interleukin 2 (IL-2) concentrations inhibited Bcl-6 expression in polarized TH1 cells. Mechanistically, the low amounts of Bcl-6 normally found in effector TH1 cells could not repress its target genes because a T-bet-Bcl-6 complex masked the Bcl-6 DNA-binding domain. TH1 cells increased their Bcl-6/T-bet ratio in response to limiting IL-2 conditions, allowing excess Bcl-6 to repress its direct target Prdm1 (which encodes Blimp-1). The Bcl-6-dependent repression of Blimp-1 effectively induced a partial TFH-profile because Blimp-1 directly repressed a subset of TFH-signature genes, including Cxcr5. Taken together, IL-2-signaling regulates the Bcl-6-Blimp-1 axis in TH1 cells to maintain flexibility with a TFH-like gene profile.
TI - Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile
JF - Nature immunology
DO - 10.1038/ni.2242
DA - 2012-03-11
UR - https://www.deepdyve.com/lp/pubmed-central/molecular-mechanisms-that-control-the-expression-and-activity-of-bcl-6-L2xhVannWI
SP - 405
EP - 411
VL - 13
IS - 4
DP - DeepDyve
ER -