TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on November 11, 2021 - Published by Cold Spring Harbor Laboratory Press The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage- induced transcription in yeast - 3 James B. Allen/'^ Zheng Zhou/-^ Wolfram Siede/ Errol C. Friedberg/ and Stephen J. Elledge^ 'Howard Hughes Medical Institute, ^Vema &. Marrs McLean Department of Biochemistry, ^histitute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030 USA; "^Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, Texas 75235 USA Inhibition of DNA synthesis prevents mitotic entry through the action of the S-phase checkpoint. We have isolated S-phase arrest-defective {sad) mutants that show lethality in the presence of the DN A synthesis inhibitor hydroxyurea (HU). Several of these mutants show phenotypes consistent with inappropriate mitotic entry in the presence of unreplicated DNA, indicating a defect in the S-phase checkpoint, sadl mutants are additionally defective for the G^ and Gj DN A damage checkpoints, and for DN A damage-induced transcription of RNR2 and RNR3. The transcriptional response to DN A damage requires activation of the Dun l protein kinase. Activation of Dun l in response to replication blocks or DN A damage is blocked in sadl mutants. The HU 
TI - The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.
JF - Genes & Development
DO - 10.1101/gad.8.20.2401
DA - 1994-10-15
UR - https://www.deepdyve.com/lp/unpaywall/the-sad1-rad53-protein-kinase-controls-multiple-checkpoints-and-dna-LABQ0qPHYQ
DP - DeepDyve
ER -