TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on October 13, 2021 - Published by Cold Spring Harbor Laboratory Press A5
 RNA element promotes dengue virus RNA synthesis on a circular genome 1 1 1 1 2,3 Claudia V. Filomatori, Maria F. Lodeiro, Diego E. Alvarez, Marcelo M. Samsa, Lía Pietrasanta, 1,3,4 and Andrea V. Gamarnik 1 2 Fundación Instituto Leloir, Buenos Aires C1405BWE, Argentina; Centro de Microscopías Avanzadas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428BEHA, Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas de Argentina, Buenos Aires C1033AAJ, Argentina The mechanisms of RNA replication of plus-strand RNA viruses are still unclear. Here, we identified the first promoter element for RNA synthesis described in a flavivirus. Using dengue virus as a model, we found that the viral RdRp discriminates the viral RNA by specific recognition of a 5
 element named SLA. We demonstrated that RNA–RNA interactions between 5
 and 3
 end sequences of the viral genome enhance dengue virus RNA synthesis only in the presence of an intact SLA. We propose a novel mechanism for minus-strand RNA synthesis in which the viral polymerase binds SLA at the 5
 end of the genome and reaches the site of initiation 
TI - A 5′ RNA element promotes dengue virus RNA synthesis on a circular genome
JF - Genes & Development
DO - 10.1101/gad.1444206
DA - 2006-08-01
UR - https://www.deepdyve.com/lp/unpaywall/a-5-rna-element-promotes-dengue-virus-rna-synthesis-on-a-circular-LEIqSOSvjw
DP - DeepDyve
ER -