TY - JOUR
AU1 - Zacharakis, Nikolaos
AU2 - Chinnasamy, Harshini
AU3 - Black, Mary
AU4 - Xu, Hui
AU5 - Lu, Yong-Chen
AU6 - Zheng, Zhili
AU7 - Pasetto, Anna
AU8 - Langhan, Michelle
AU9 - Shelton, Thomas
AU1 - Prickett, Todd
AU1 - Gartner, Jared
AU1 - Jia, Li
AU1 - Trebska-McGowan, Katarzyna
AU1 - Somerville, Robert
AU1 - Robbins, Paul
AU1 - Rosenberg, Steven
AU1 - Goff, Stephanie
AU1 - Feldman, Steven
AB - Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-induced lung cancers and bladder cancer—with little effect in other common epithelial cancers that have lower mutation rates, such as those arising in the gastrointestinal tract, breast and ovary
1–7
. Adoptive transfer of autologous lymphocytes that specifically target proteins encoded by somatically mutated genes has mediated substantial objective clinical regressions in patients with metastatic bile duct, colon and cervical cancers
8–11
. We present a patient with chemorefractory hormone receptor (HR)-positive metastatic breast cancer who was treated with tumor-infiltrating lymphocytes (TILs) reactive against mutant versions of four proteins—SLC3A2, KIAA0368, CADPS2 and CTSB. Adoptive transfer of these mutant-protein-specific TILs in conjunction with interleukin (IL)-2 and checkpoint blockade mediated the complete durable regression of metastatic breast cancer, which is now ongoing for >22 months, and it represents a new immunotherapy approach for the treatment of these patients.
TI - Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
JF - Nature Medicine
DO - 10.1038/s41591-018-0040-8
DA - 2018-06-04
UR - https://www.deepdyve.com/lp/springer-journals/immune-recognition-of-somatic-mutations-leading-to-complete-durable-LKCl7yKqTs
SP - 724
EP - 730
VL - 24
IS - 6
DP - DeepDyve
ER -