TY - JOUR
AU1 - Srebro, Dragana
AU2 - Vučković, Sonja
AU3 - Milovanović, Aleksandar
AU4 - Vujović, Katarina
AU5 - Vučetić, Čedomir
AU6 - Prostran, Milica
AB - Dizocilpine is a highly selective and potent non-competitive antagonist of the N-methyl-d -aspartate (NMDA) glutamate receptor. It is well known that dizocilpine has different neuroprotective effects in animal models of pain, epilepsy and oedema during trauma. The search for alternative antiinflammatory drugs is ongoing. We investigated the anti-oedematous effects of dizocilpine and the probable mechanism of action in a rat model that mimics local and persistent inflammation without tissue injury or damage. Male Wistar rats were injected with 100 μL of 0.5% carrageenan to the plantar surface of the hind paw. Anti-oedematous activity was assessed in the carrageenan-induced paw inflammatory oedema test with a plethysmom - eter. To assess possible mechanisms of dizocilpine action, we examined the effects of the selective inhibitor of neuronal [N-ω-propyl-l -arginine hydrochloride (L-NPA)] and inducible [S-methylisothiourea (SMT)] nitric oxide synthase (NOS). Dizocilpine after systemic (0.0005, 0.005 and 0.02 mg/kg, subcutaneous (s.c.)), but not after local peripheral administra- tion, reduced the paw inflammatory oedema. The effect is not dose dependent, and the highest decrease by about 47% at the time of maximally developed oedema was achieved with 0.005 mg/kg. Intraperitoneally (i.p.) administered L-NPA (0.5, 1 and 2 mg/kg) or SMT (0.005, 0.01 and 0.015 mg/kg) before dizocilpine abolished or reduced 
TI - Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling
JF - Inflammopharmacology
DO - 10.1007/s10787-018-0526-5
DA - 2018-09-04
UR - https://www.deepdyve.com/lp/springer-journals/preventive-treatment-with-dizocilpine-attenuates-oedema-in-a-Lg7b0s1f3P
SP - 1
EP - 8
VL - OnlineFirst
IS - 
DP - DeepDyve
ER -