TY - JOUR AU - Ecker, Brett L. AB - Ann Surg Oncol https://doi.org/10.1245/s10434-025-17605-1 ASO AUTHOR REFLECTIONS ASO Author Reflections: Improved Access, Improved Outcomes: Regional Increases of Curative‑Intent Liver Therapies Are Associated with Improved Survival in Patients with CRCLM 1 2,3,4 Vasileios Tsagkalidis, MD , and Brett L. Ecker, MD 1 2 Division of Surgical Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ; Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; Cooperman Barnabas Medical Center, Livingston, NJ PAST allows each area to serve as its own control while adjusting for observed changes in the patient population over time. Colorectal cancer is the second leading cause of cancer Given that approximately one fifth of resection patients death in the USA. Liver-directed therapies—including demonstrate long-term survival, we hypothesized that each hepatectomy, ablation, and transplantation—are the cor- 5% rise in the regional rate of interventions would lead to a nerstone of curative treatment for patients with colorectal 1% increase in population-level survival. In accordance, we cancer liver metastases (CRCLM). There are no randomized observed that each 5% increase in the rate of liver therapies data to confirm the survival benefit of these interventions within an HSA was associated with a statistically signic fi ant compared with systemic therapy alone, with prior stud- 1.2% (95% confidence TI - ASO Author Reflections: Improved Access, Improved Outcomes: Regional Increases of Curative-Intent Liver Therapies Are Associated with Improved Survival in Patients with CRCLM JF - Annals of Surgical Oncology DO - 10.1245/s10434-025-17605-1 DA - 2025-06-02 UR - https://www.deepdyve.com/lp/springer-journals/aso-author-reflections-improved-access-improved-outcomes-regional-LiDSO0Ezk6 SP - 1 EP - 2 VL - OnlineFirst IS - DP - DeepDyve ER -