TY - JOUR
AU1 - Park, Jungyul
AU2 - Kim, Il Chaek
AU3 - Cha, Jaemin
AU4 - Park, Sukho
AU5 - Lee, Junghoon
AU6 - Kim, Byungkyu
AB - A novel platform is developed to study the mechanotransduction of cardiomyocytes. After the cardiomyocytes are seeded on 10 µm thin, dome-shaped membranes with different sizes, their morphology and beating frequency are monitored. While the cells seeded on a larger membrane (800 µm × 800 µm) grow normally, cells on a smaller membrane (200 µm × 200 µm) grow in isolated groups, showing a lumped morphology. The beating frequency of the cells on the smaller membrane was faster than on the larger membrane. This intriguing phenomenon may be explained by the mechanical stress determined by the area of the membrane that affects the opening of ion channels.
TI - Mechanotransduction of cardiomyocytes interacting with a thin membrane transducer
JF - Journal of Micromechanics and Microengineering
DO - 10.1088/0960-1317/17/6/009
DA - 2007-06-01
UR - https://www.deepdyve.com/lp/iop-publishing/mechanotransduction-of-cardiomyocytes-interacting-with-a-thin-membrane-Mt350VqSAH
SP - 1162
VL - 17
IS - 6
DP - DeepDyve
ER -