TY - JOUR
AU - Chen, Quan
AB - Receptor-mediated mitophagy is one of the major mechanisms of mitochondrial quality control essential for cell survival. We previously have identified FUNDC1 as a mitophagy receptor for selectively removing damaged mitochondria in mammalian systems. A critical unanswered question is how receptor-mediated mitophagy is regulated in response to cellular and environmental cues. Here, we report the striking finding that BCL2L1/Bcl-xL, but not BCL2, suppresses mitophagy mediated by FUNDC1 through its BH3 domain. Mechanistically, we demonstrate that BCL2L1, but not BCL2, interacts with and inhibits PGAM5, a mitochondrially localized phosphatase, to prevent the dephosphorylation of FUNDC1 at serine 13 (Ser13), which activates hypoxia-induced mitophagy. Our results showed that the BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy in response to hypoxia and that BCL2L1 possesses unique functions distinct from BCL2.
TI - The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy
JF - Autophagy
DO - 10.4161/auto.29568
DA - 2014-10-17
UR - https://www.deepdyve.com/lp/taylor-francis/the-bcl2l1-and-pgam5-axis-defines-hypoxia-induced-receptor-mediated-N0A3qcrM0M
SP - 1712
EP - 1725
VL - 10
IS - 10
DP - DeepDyve
ER -