TY - JOUR
AU - Leijnse,  B.
AB - 213 8 8 1 1 H. M. van Praag B. Leijnse Department of Psychiatry Dijkzigt Hospital Rotterdam The Netherlands Department of Biochemistry Dijkzigt Hospital Rotterdam The Netherlands Summary In a group of depressive patients a study was made of the influence of isocarboxazid on hunger sensations, on the peripheral glucose uptake and on the mobilization of glucose from liver glycogen. The group was symptomatologically homogeneous: all patients showed the symptoms of the vital depressive syndrome. We established the following. 1. In the group of patients showing improvement upon isocarboxazid medication (group A), the Δ glucose value prior to treatment was significantly lower than that in the group of patients refractory to this drug (group B). During medication the Δ glucose value showed a distinct increase, and after treatment it remained at a normal level. 2. Group B showed a tendency corresponding to that in group A, but this just escaped attaining the level of statistical significance. 3. Mayer's glucostatic theory of hunger regulation was not corroborated. 4. Isocarboxazid does not demonstrably inhibit intrahepatic glycogenolysis. In a previous study we demonstrated that the therapeutic effect of anti-depressive hydrazines is accompanied by an increase in glucose tolerance. It is assumed that the increased extrahepatic glucose uptake now observed is responsible for this phenomenon. Finally it is concluded that (in view of the composition of groups A and B) metabolic factors must be considered in addition to the psychopathological features when using anti-depressive hydrazines.
TI - Depression, glucose tolerance, peripheral glucose uptake and their alterations under the influence of anti-depressive drugs of the hydrazine type
JF - Psychopharmacology
DO - 10.1007/BF00405362
DA - 1965-01-01
UR - https://www.deepdyve.com/lp/springer-journals/depression-glucose-tolerance-peripheral-glucose-uptake-and-their-N2J0r7k1HN
SP - 67
EP - 78
VL - 8
IS - 1
DP - DeepDyve
ER -