TY - JOUR
AU - Elinav, Eran
AB - 


A narrow definition of dysbiosis is as a stable microbial community state that functionally contributes to the aetiology, diagnosis or treatment of a disease.


Dysbiosis is often driven by infection and inflammation, diet and xenobiotics, host genetics or the host's environment.


Innate and adaptive immunity control the colonization niche of the intestinal microbiota through mechanisms including the production of antimicrobial peptides and IgA antibodies.


A dysbiotic microbiota may actively influence its colonization niche by altering the functions of innate and adaptive intestinal immunity.


Dysbiosis has been associated with many immune-related human diseases, but in many cases it remains to be established whether dysbiosis is a cause or consequence of the disease.


Personalized nutrition and metabolite-based 'postbiotic' therapy may present ways in which to harness the increasing knowledge about dysbiosis in disease for the design of new therapies.



TI - Dysbiosis and the immune system
JF - Nature Reviews Immunology
DO - 10.1038/nri.2017.7
DA - 2017-03-06
UR - https://www.deepdyve.com/lp/springer-journals/dysbiosis-and-the-immune-system-N5BlPCSBEO
SP - 219
EP - 232
VL - 17
IS - 4
DP - DeepDyve
ER -