TY - JOUR
AU1 - Suganuma, Masami
AU2 - Kurusu, Miki
AU3 - Suzuki, Kaori
AU4 - Nishizono, Akira
AU5 - Murakami, Kazunori
AU6 - Fujioka, Toshio
AU7 - Fujiki, Hirota
AB - J Cancer Res Clin Oncol (2005) 131: 305–313 DOI 10.1007/s00432-004-0652-x ORIGINAL PAPER Masami Suganuma Æ Miki Kurusu Æ Kaori Suzuki Akira Nishizono Æ Kazunori Murakami Æ Toshio Fujioka Hirota Fujiki New tumor necrosis factor-a-inducing protein released from Helicobacter pylori for gastric cancer progression Received: 8 October 2004 / Accepted: 25 October 2004 / Published online: 23 December 2004 Springer-Verlag 2004 Abstract Purpose: To investigate the association between Introduction Helicobacter pylori infection and its inflammatory reac- tion in gastritis, gastric ulcer, and gastric cancer, a new It is now generally accepted that Helicobacter pylori tumor necrosis factor-a (TNF-a)-inducing protein of infection induces local inflammation in the stomach H. pylori was studied. Methods: The HP0596 gene of associated with induction of proinflammatory cyto- H. pylori was identified as the TNF-a-inducing protein kines, such as tumor necrosis factor-a (TNF-a), (Tipa) gene from genome sequence of H. pylori strain interleukine-1 (IL-1), and IL-8. The infection can lead 26695. Using recombinant Tipa (rTipa) and deleted Tipa to gastritis, gastric ulcer, and then stomach cancer in (rdel-Tipa) proteins, the latter of which lacks six amino humans (Correa 2003; IARC Working Group 1994; acids containing two cysteines in the N-terminal do- Normark et al. 2003; Peek 
TI - New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression
JF - Journal of Cancer Research and Clinical Oncology
DO - 10.1007/s00432-004-0652-x
DA - 2004-12-23
UR - https://www.deepdyve.com/lp/springer-journals/new-tumor-necrosis-factor-inducing-protein-released-from-helicobacter-NSqaFfvfJ3
SP - 305
EP - 313
VL - 131
IS - 5
DP - DeepDyve
ER -