TY - JOUR
AU - Engelhard, V H
AB - Peptides extracted from HLA-A2.1 class I major histocompatibility complex (MHC) molecules expressed on the antigen processing mutant CEMx721.174.T2 were characterized by electrospray ionization-tandem mass spectrometry. Only seven dominant peptides were found, in contrast to over 200 associated with HLA-A2.1 on normal cells. These peptides were derived from the signal peptide domains of normal cellular proteins, were usually larger than nine residues, and were also associated with HLA-A2.1 in normal cells. These results suggest that proteolysis of signal peptide domains in the endoplasmic reticulum is a second mechanism for processing and presentation of peptides for association with class I molecules.
TI - HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1546329
DA - 1992-04-13
UR - https://www.deepdyve.com/lp/pubmed/hla-a2-1-associated-peptides-from-a-mutant-cell-line-a-second-pathway-Nt01phKy3m
SP - 1264
EP - 6
VL - 255
IS - 5049
DP - DeepDyve
ER -