TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275, No. 32, Issue of August 11, pp. 24735–24739, 2000 © 2000 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27* Received for publication, March 6, 2000, and in revised form, June 6, 2000 Published, JBC Papers in Press, June 19, 2000, DOI 10.1074/jbc.C000147200 Heng-Yin Yang‡§, Binhua P. Zhou‡¶, Mien-Chie Hung‡i**, and Mong-Hong Lee‡i**‡‡ From the Departments of ‡Molecular Cellular Oncology and iSurgical Oncology, **Breast Cancer Research Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 Overexpression and activation of HER-2/neu, a pro- pendent kinase inhibitors, including the Inhibitor of CDK4 family and the CIP/KIP family, are negative regulators (4). to-oncogene, play a pivotal role in cancer formation. Strong expression of HER-2/neu in cancers has been as- p27, a CIP/KIP member, encodes a cyclin-dependent kinase sociated with poor prognosis. Reduced expression of inhibitor that causes G arrest by inhibiting the activities of Kip1 p27 , a cyclin-dependent kinase inhibitor, correlates G cyclin-CDKs. As a negative regulator of the cell cycle, p27 is with poor clinical outcome in many types of carcinomas. 
TI - Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.c000147200
DA - 2000-08-01
UR - https://www.deepdyve.com/lp/unpaywall/oncogenic-signals-of-her-2-neu-in-regulating-the-stability-of-the-O7kCl5KHkN
DP - DeepDyve
ER -