TY - JOUR
AU - de Bont, Eveline S. J. M.
AB - Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been implicated in tumor progression, making MSCs important targets for anti-cancer strategies. In this study, we show that MSCs promote tumor growth in vivo in a lymphoma xenograft model. We show that MSCs provide direct cell–cell contact interactions and, to a lesser extend, soluble factors that promote tumor cell proliferation and survival in vitro. PTK787/ZK 222584 reduces tumor growth-promoting effects of MSCs both in vitro and in vivo. Our results address the importance of targeting the MSCs for future anti-cancer strategies.
TI - Mesenchymal Stem Cells Contribute to Tumor Cell Proliferation by Direct Cell-Cell Contact Interactions
JO - Cancer Investigation
DO - 10.3109/07357900903179625
DA - 2010-05-01
UR - https://www.deepdyve.com/lp/taylor-francis/mesenchymal-stem-cells-contribute-to-tumor-cell-proliferation-by-OhPrshUjmp
SP - 526
EP - 534
VL - 28
IS - 5
DP - DeepDyve
ER -