TY - JOUR
AU - Incarnato, Danny
AB - RNA structure heterogeneity is a major challenge when querying RNA structures with chemical probing. We introduce DRACO, an algorithm for the deconvolution of coexisting RNA conformations from mutational profiling experiments. Analysis of the SARS-CoV-2 genome using dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq) and DRACO, identifies multiple regions that fold into two mutually exclusive conformations, including a conserved structural switch in the 3′ untranslated region. This work may open the way to dissecting the heterogeneity of the RNA structurome.
TI - Genome-scale deconvolution of RNA structure ensembles
JF - Nature Methods
DO - 10.1038/s41592-021-01075-w
DA - 2021-03-01
UR - https://www.deepdyve.com/lp/springer-journals/genome-scale-deconvolution-of-rna-structure-ensembles-PSwmUNeanR
SP - 249
EP - 252
VL - 18
IS - 3
DP - DeepDyve
ER -