TY - JOUR AU - Forgacs, Gabor AB - Chapter 2 COMPLEXITY AND SELF-ORGANIZATION IN BIOLOGICAL DEVELOPMENT AND EVOLUTION Stuart A. Newman New York Medical College, Valhalla, NY 10595 Gabor Forgacs University of Missouri, Columbia, MO 65211 1. Introduction: Complex Chemical Systems in Biological Development and Evolution The field of developmental biology has as its major concern embryoge- nesis: the generation of fully-formed organisms from a fertilized egg, the zygote. Other issues in this field, organ regeneration and tissue repair in organisms that have already passed through the embryonic stages, have in common with embryogenesis three interrelated phenomena: cell differentiation, the production of distinct cell types, cell pattern formation, the generation of specific spatial arrangements of cells of different types, and morphogenesis, the molding and shaping of tissues [1]. The cells involved in these developmental processes and outcomes generally have the same genetic information encoded in their DNA, the genome of the organism, so that the different cell behaviors are largely assocated with differential gene expression. Because of the ubiquity and importance of differential gene expression during development, and the fact that each type of organism has its own unique genome, a highly gene-centered view of development prevailed for several decades after the discovery of DNA’s capacity to TI - Complexity in Chemistry, Biology, and Ecology: Complexity and Self-Organization in Biological Development and Evolution DA - 2005-01-01 UR - https://www.deepdyve.com/lp/springer-journals/complexity-in-chemistry-biology-and-ecology-complexity-and-self-PZZR48xu7R DP - DeepDyve ER -