TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 31, Issue of July 30, pp. 32116 –32124, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex* Received for publication, February 27, 2004, and in revised form, May 13, 2004 Published, JBC Papers in Press, May 20, 2004, DOI 10.1074/jbc.M402230200 Elena B. Tikhonova and Helen I. Zgurskaya‡ From the Department of Chemistry and Biochemistry, the University of Oklahoma, Norman, Oklahoma 73019 periplasm. In this case, the transport is achieved without a Many transporters of Gram-negative bacteria in- volved in the extracellular secretion of proteins and the periplasmic intermediate. Numerous transporters of Gram- efflux of toxic molecules operate by forming intermem- negative bacteria involved in the extracellular secretion of pro- brane complexes. These complexes are proposed to span tein and the efflux of toxic molecules were shown to operate by both inner and outer membranes and create a bridge forming intermembrane complexes (reviewed in Refs. 2 and 3). across the periplasm. In this study, we analyzed inter- In the latter case this feature is particularly important, be- actions between the inner 
TI - AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m402230200
DA - 2004-07-01
UR - https://www.deepdyve.com/lp/unpaywall/acra-acrb-and-tolc-of-escherichia-coli-form-a-stable-intermembrane-Q1Pjq5E04X
DP - DeepDyve
ER -