TY - JOUR AU - AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 33, pp. 22041–22047, August 14, 2009 © 2009 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. Received for publication, April 2, 2009, and in revised form, April 23, 2009 Published, JBC Papers in Press, June 19, 2009, DOI 10.1074/jbc.M109.002964 ‡1 ‡1 § ‡2 Cle´ment Faye , Emilie Chautard , Bjorn R. Olsen , and Sylvie Ricard-Blum From the Institut de Biologie et Chimie des Prote´ines, UMR 5086 CNRS, University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France and the Department of Developmental Biology, Harvard School of Dental Medicine and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 Endostatin is a C-terminal proteolytic fragment of collagen signaling systems are involved in mediation of its antiangiogenic XVIII that is localized in vascular basement membrane zones in action. Endostatin is a broad spectrum angiogenesis inhibitor that various organs. It binds to heparin/heparan sulfate and to a suppresses angiogenesis by blocking general mechanisms that number of proteins, but its molecular mechanisms of action are govern endothelial cell growth (14), and initiates a complex net- not fully elucidated. We TI - The First Draft of the Endostatin Interaction Network JF - Journal of Biological Chemistry DO - 10.1074/jbc.m109.002964 DA - 2009-08-01 UR - https://www.deepdyve.com/lp/unpaywall/the-first-draft-of-the-endostatin-interaction-network-Q2XqXFasOD DP - DeepDyve ER -