TY - JOUR
AU - Wong, Chi-Huey
AB - The knowledge accumulated through the last two decades about the structure and the mechanism of HIV PR has paved the way towards the development of effective drugs for this enzyme. In addition, there is a huge amount of information regarding the design of inhibitors for other aspartic proteases, such as renin, which is involved in the control of hypertension. Although there are no clinically useful renin inhibitors today, the lessons learned from the drug discovery process towards finding effective drugs for this enzyme have assisted researchers in finding effective drugs for HIV PR. In addition to design, random screening and combination of these approaches have accelerated the drug discovery process. There are today six FDA approved drugs that function as inhibitors for HIV PR ().
TI - HIV-1 protease: mechanism and drug discovery
JF - Organic & Biomolecular Chemistry
DO - 10.1039/b208248a
DA - 2003-12-19
UR - https://www.deepdyve.com/lp/royal-society-of-chemistry/hiv-1-protease-mechanism-and-drug-discovery-QZWrP01ZbL
SP - 5
EP - 14
VL - 1
IS - 1
DP - DeepDyve
ER -