TY - JOUR
AU - Zerbe, Oliver
AB -  by Nadja Bross-Walch a ), Till Kühn b ), Detlef Moskau b ), and Oliver Zerbe* a ) ) Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich (phone: ‡ 41-1-635 42 63; fax: ‡ 41-1-635 68 33; e-mail: oliver.zerbe@oci.unizh.ch) b ) Bruker Biospin, Industriestrasse, CH-8137 Fällanden Introduction. ± Modern spectroscopic methods have largely revolutionized compound identification and tremendously accelerated the pace at which isolated compounds can be identified nowadays. It is hard to believe that 50 years ago compounds still required tedious decomposition into known fragments, or, alternatively, total chemical synthesis to corroborate the proposed structures. However, when compound quantities are very small, total chemical synthesis for independent structure elucidation is still being performed in important cases. Following the discovery of the nuclear magnetic resonance (NMR) phenomenon by physicists, chemists quickly recognized its use for the identification of organic compounds, and NMR instruments entered the laboratories of chemists. The early days of NMR were characterized by establishing empirical rules through which chemical-shift information was translated into covalent and stereochemical information. Inevitably, extraction of chemical shifts was hampered by the poor resolution of the low-field instruments in those days, which also contributed to problems associated with 
TI - Strategies and Tools for Structure Determination of Natural Products Using Modern Methods of NMR Spectroscopy
JF - Chemistry & Biodiversity
DO - 10.1002/cbdv.200590000
DA - 2005-02-01
UR - https://www.deepdyve.com/lp/wiley/strategies-and-tools-for-structure-determination-of-natural-products-QwzBIcKBcS
SP - 147
EP - 177
VL - 2
IS - 2
DP - DeepDyve
ER -