TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277, No. 36, Issue of September 6, pp. 33049 –33057, 2002 © 2002 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. MCM2–7 Complexes Bind Chromatin in a Distributed Pattern Surrounding the Origin Recognition Complex in Xenopus Egg Extracts* Received for publication, May 7, 2002, and in revised form, June 25, 2002 Published, JBC Papers in Press, June 26, 2002, DOI 10.1074/jbc.M204438200 Melissa C. Edwards‡, Antonin V. Tutter, Christin Cvetic, Catherine H. Gilbert, Tatyana A. Prokhorova, and Johannes C. Walter§ From the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 The MCM2–7 complex is believed to function as the loci, initiation events are distributed throughout zones span- eukaryotic replicative DNA helicase. It is recruited to ning up to 50 kb. chromatin by the origin recognition complex (ORC), The mechanism of DNA replication initiation is highly con- /S transition Cdc6, and Cdt1, and it is activated at the G 1 served among eukaryotic organisms (3, 4). A representative by Cdc45 and the protein kinases Cdc7 and Cdk2. Para- model system is Xenopus egg extracts (2, 4) where two factors, doxically, the number of chromatin-bound MCM 
TI - MCM2–7 Complexes Bind Chromatin in a Distributed Pattern Surrounding the Origin Recognition Complex inXenopus Egg Extracts
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m204438200
DA - 2002-09-01
UR - https://www.deepdyve.com/lp/unpaywall/mcm2-7-complexes-bind-chromatin-in-a-distributed-pattern-surrounding-QyizfV5PYA
DP - DeepDyve
ER -