TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273, No. 49, Issue of December 4, pp. 32377–32379, 1998 Communication © 1998 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. that CREB and its paralog CREM are important for cell sur- CREB Is a Regulatory Target for vival. CREM-deficient mice, for example, exhibit a spermato- the Protein Kinase Akt/PKB* genesis defect secondary to enhanced apoptosis of germ cells (17, 18). Overexpression of a dominant negative CREB trans- (Received for publication, September 11, 1998, and in revised gene, moreover, induces apoptosis in T cells, following growth form, October 5, 1998) factor stimulation (19). The involvement of CREB family mem- Keyong Du and Marc Montminy‡ bers in cell survival and the resemblance of Akt/PKB to protein kinase A, not only in primary sequence but also in its apparent From the Joslin Diabetes Center, Research Division, Department of Cell Biology, Harvard Medical School, substrate specificity, prompted us to examine whether CREB is Boston, Massachusetts 02215 a regulatory target for Akt/PKB. Here we demonstrate that Akt/PKB promotes phosphorylation of CREB, stimulates re- The nuclear factor CREB stimulates the expression of cruitment of CBP to the promoter, and activates cellular gene cellular 
TI - CREB Is a Regulatory Target for the Protein Kinase Akt/PKB
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.273.49.32377
DA - 1998-12-01
UR - https://www.deepdyve.com/lp/unpaywall/creb-is-a-regulatory-target-for-the-protein-kinase-akt-pkb-Rzw9RTkBhW
DP - DeepDyve
ER -