TY - JOUR AU - Bugg, C E AB - The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions. TI - Three-dimensional structure of recombinant human interferon-gamma. JF - Science (New York, N.Y.) DO - 10.1126/science.1902591 DA - 1991-05-31 UR - https://www.deepdyve.com/lp/pubmed/three-dimensional-structure-of-recombinant-human-interferon-gamma-SE248GSbcF SP - 698 EP - 702 VL - 252 IS - 5006 DP - DeepDyve ER -