TY - JOUR
AU - Bugg, C E
AB - The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.
TI - Three-dimensional structure of recombinant human interferon-gamma.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1902591
DA - 1991-05-31
UR - https://www.deepdyve.com/lp/pubmed/three-dimensional-structure-of-recombinant-human-interferon-gamma-SE248GSbcF
SP - 698
EP - 702
VL - 252
IS - 5006
DP - DeepDyve
ER -