TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274, No. 41, Issue of October 8, pp. 29331–29340, 1999 © 1999 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Methylation Sequencing Analysis Refines the Region of H19 Epimutation in Wilms Tumor* (Received for publication, April 27, 1999, and in revised form, July 10, 1999) Mathias A. E. Frevel‡§, Stephen J. Sowerby¶, George B. Petersen¶, and Anthony E. Reeve‡ From the ‡Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, and ¶Department of Biochemistry, University of Otago, P. O. Box 56, Dunedin 9001, New Zealand Differential DNA methylation of the parental alleles 11p15.5 that is syntenic with the mouse distal chromosome 7. The maternally imprinted IGF2 gene is transcribed only from has been implicated in the establishment and mainte- nance of the monoallelic expression of imprinted genes. the paternal allele in most normal human tissues except for H19 and IGF2 are oppositely imprinted with only the adult liver, choroid plexus, and leptomeninges (1, 2). In con- maternal and the paternal alleles expressed, respec- trast, the H19 gene is paternally imprinted hence maternally tively. In Wilms tumor, a childhood renal neoplasm, loss transcribed (3–5). This reciprocal expression pattern is 
TI - Methylation Sequencing Analysis Refines the Region ofH19 Epimutation in Wilms Tumor
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.274.41.29331
DA - 1999-10-01
UR - https://www.deepdyve.com/lp/unpaywall/methylation-sequencing-analysis-refines-the-region-ofh19-epimutation-SF9K0s2OzY
DP - DeepDyve
ER -