TY - JOUR
AU - Georges, Michel
AB - © 1999 Nature America Inc. • http://genetics.nature.com correspondence (Fig. 1). Subsequent sequence analysis An imprinted QTL with major effect demonstrated that the microsatellite marker SWC9 is actually located in the 3´ on muscle mass and fat deposition UTR of IGF2 (L. Andersson, pers. comm.). FISH analysis performed with a BAC clone maps to the IGF2 locus in pigs containing porcine IGF2 demonstrated the terminal location of this gene on SSC2p (ref. 7), making a more distal location of e have generated an intercross positioned MYOD1 in the SW240-SW776 the identified QTL unlikely. W between Large White and Piétrain interval by linkage analysis (odds>1,000), IGF2 therefore appeared to be a posi- pig strains yielding 1,032 F offspring as well outside the lod-2 drop-off support tional candidate for the observed QTL described . The Large White and Piétrain interval for the QTL (Fig. 1a). On the basis effect. In man and mouse, IGF2 is parental breeds differ in a number of eco- of a published porcine adult liver cDNA imprinted and expressed exclusively from 5 8 nomically important phenotypes. Pié- sequence , we designed primer pairs to the paternal allele in several tissues . We trains are known for exceptional amplify 
TI - An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs
JF - Nature Genetics
DO - 10.1038/5935
DA - 1999-02-01
UR - https://www.deepdyve.com/lp/springer-journals/an-imprinted-qtl-with-major-effect-on-muscle-mass-and-fat-deposition-SHCZONr0kf
SP - 155
EP - 156
VL - 21
IS - 2
DP - DeepDyve
ER -