TY - JOUR
AU1 - Nakamura, Toshiaki
AU2 - Shirakata, Yoshinori
AU3 - Shinohara, Yukiya
AU4 - Miron, Richard
AU5 - Hasegawa-Nakamura, Kozue
AU6 - Fujioka-Kobayashi, Masako
AU7 - Noguchi, Kazuyuki
AB - Clin Oral Invest (2017) 21:2671–2679 DOI 10.1007/s00784-017-2069-3 ORIGINAL ARTICLE Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects 1 1 1 2 Toshiaki Nakamura & Yoshinori Shirakata & Yukiya Shinohara & Richard J. Miron & 1 3,4 1 Kozue Hasegawa-Nakamura & Masako Fujioka-Kobayashi & Kazuyuki Noguchi Received: 19 October 2016 /Accepted: 31 January 2017 /Published online: 14 February 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract NBA), central bone height (CBH), and marginal bone height Objectives Among bone morphogenetic protein (BMP) fam- (MBH) by histomorphometric analysis. ily members, BMP-2 and BMP-9 have demonstrated potent Results The BV in the rhBMP-2/ACS group osteoinductive potential. However, in vivo differences in their (5.44 ± 3.65 mm , n = 7) was greater than the other groups potential for bone regeneration remain unclear. The present at 2 weeks post-surgery, and the rhBMP-2/ACS and rhBMP- study aimed to compare the effects of recombinant human 9/ACS groups (18.17 ± 2.51 and 16.30 ± 2.46 mm , n =7, (rh) BMP-2 and rhBMP-9 on bone formation in rat calvarial respectively) demonstrated significantly greater amounts of critical-size defects (CSD). BV compared with the control and ACS groups (6.02 
TI - Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects
JF - Clinical Oral Investigations
DO - 10.1007/s00784-017-2069-3
DA - 2017-02-14
UR - https://www.deepdyve.com/lp/springer-journals/comparison-of-the-effects-of-recombinant-human-bone-morphogenetic-Sr1hOK5tcm
SP - 2671
EP - 2679
VL - 21
IS - 9
DP - DeepDyve
ER -