TY - JOUR
AU - Aitman, Timothy J
AB - Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 × 10−8), microscopic polyangiitis (P = 2.9 × 10−4) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 × 10−3) and France (P = 1.1 × 10−4). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.
TI - FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
JF - Nature Genetics
DO - 10.1038/ng2046
DA - 2007-05-21
UR - https://www.deepdyve.com/lp/springer-journals/fcgr3b-copy-number-variation-is-associated-with-susceptibility-to-SyPL3lE0Ch
SP - 721
EP - 723
VL - 39
IS - 6
DP - DeepDyve
ER -